The abundance of diverse naive CD8^(+) T cell clones is essential for broad protection against infection and cancer, but how sex and aging jointly shape this compartment remains poorly understood. Here, using mouse models with supporting human data, we uncover a sex-biased mechanism of immune aging in which early male-biased depletion of naive CD8^(+) T cells driven by accelerated, antigen-agnostic differentiation into virtual memory cells combines with thymic involution, limiting naive CD8^(+)…

CONCLUSIONS: Among patients with newly diagnosed atrial fibrillation at high risk for ischemic stroke, OAC prescribing at diagnosis was suboptimal, and loss of documented OAC prescribing was common during the first year. Baseline OAC use was more strongly associated with bleeding risk, frailty, and comorbidity burden, and less consistently aligned with ischemic stroke risk.

CONCLUSIONS: Diabetes, but not prediabetes, was independently associated with rapid progression of coronary atherosclerosis. Furthermore, the higher incidence of RPP among participants who developed new-onset diabetes suggests that the development of diabetes may represent an important threshold for accelerated coronary plaque progression.