Higher abundance of micro- and nanoplastics in inflammatory tissues from patients with intestinal erosion

Higher abundance of micro- and nanoplastics in inflammatory tissues from patients with intestinal erosion

The detrimental effects of micro- and nanoplastics (MNPs) on human health have been the subject of intense research in recent years, but there is little data on how MNPs affect intestinal health. Six participants with colonic or terminal ileal erosion were enrolled, and one erosive tissue sample plus one adjacent non-erosive tissue sample were collected from each participant. Pyrolysis gas chromatography/mass spectrometry (Py-GC/MS) was utilized to determine the MNP content of these tissues…
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ECG Criteria for Left Ventricular Hypertrophy in Hypertensive Black Africans: Insights from the coArtHA Trial

ECG Criteria for Left Ventricular Hypertrophy in Hypertensive Black Africans: Insights from the coArtHA Trial

CONCLUSIONS: In this cohort of hypertensive Black African adults, ECG criteria showed a moderate association with LVMI by echocardiography. Among established ECG criteria, Cornell voltage product-based measures demonstrated the most consistent diagnostic performance. Diagnostic characteristics were strongly influenced by cut-off selection and clinical context, underscoring the need for population-specific evaluation and external validation of ECG criteria for LVH in African settings.
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Predicting stroke risk through the neutrophil-to-albumin ratio: A NHANES-based study with clinical validation

Predicting stroke risk through the neutrophil-to-albumin ratio: A NHANES-based study with clinical validation

Stroke is a major global health issue, and inflammation plays a key role in its pathogenesis. The neutrophil-to-albumin ratio (NPAR) is a novel inflammatory biomarker reflecting inflammation and oxidative stress. However, its association with stroke remains unclear. This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) 1999-2020. The association between NPAR and stroke was assessed by determining NPAR and employing various analytical methods,…
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Prenatal exposure to polystyrene nanoplastics caused testicular development toxicities and relative mechanisms in male offspring mice from embryo to adulthood

Prenatal exposure to polystyrene nanoplastics caused testicular development toxicities and relative mechanisms in male offspring mice from embryo to adulthood

Polystyrene nanoplastics (PS-NPs) are extensively present in the environment. Population studies have confirmed the presence of micro- and nanoplastics in human blood and placental tissues, and animal experiments found PS-NPs had potential developmental and reproductive toxicity. However, the continuous effects of prenatal PS-NPs exposure on testicular differentiation and development in offspring from embryo to adult are not clear. Therefore, this study aimed to investigate potential toxicity of…
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