Research - RCS Experience

Racial differences in lifetime healthcare costs associated with obesity-related multimorbidity among the U.S. population aged 40 years or older

CONCLUSIONS: Racial differences in LHC’s and LCD associated with ORM persist and the scale varies by subpopulation. Future interventions designed to prevent/manage ORM are crucial to prioritize populations burdening with high LHC’s and health disparities.

National trends in heart failure and hyperlipidemia related mortality in the United States, 1999-2024: Demographic and regional disparities with machine learning based forecasting to 2035

Cardiovascular disease remains the leading cause of death in the United States, with heart failure (HF) and hyperlipidemia substantially contributing to mortality. This study aimed to examine national trends in HF-related mortality with coexisting hyperlipidemia from 1999 to 2024 and project future mortality patterns through 2035. Mortality data were obtained from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database. Deaths were…

The exposome and inflammatory bowel disease: a framework for primary and primordial prevention

The role of the environment in inflammatory bowel disease (IBD) is acknowledged as being critical, yet enquiry into the exposome and IBD is limited. Recognizing the exposome as encompassing all physical, chemical, biological and psychosocial factors that influence human health over the lifespan is central to unravelling its role in IBD, as well as overlapping immune-mediated diseases. Here, we summarize the latest in exposome research in IBD, differentiate between early life and later exposures,…

Microplastics in food production systems: Sources, exposure pathways, and gastrointestinal health effects

Microplastics (MPs) and nanoplastics (NPs) have become ubiquitous contaminants in food production systems, raising increasing concerns regarding their potential effects on gastrointestinal and systemic health. This review summarizes current evidence on the occurrence, sources, and biological effects of MPs/NPs within food production chains and their implications for the human gut. Experimental in vitro studies demonstrate that MPs/NPs can induce oxidative stress, inflammation, genotoxicity,…