Layer cellulose-based sandwich sponge with directionally aligned channels for rapid removal of polystyrene nanoplastics and TBBPA

Layer cellulose-based sandwich sponge with directionally aligned channels for rapid removal of polystyrene nanoplastics and TBBPA

Nanoplastics can adsorb organic pollutants and facilitate their transport in water environments, thereby increasing potential risks to ecosystems and human health. However, most porous adsorbents have an even structure, making it difficult to combine rapid pollutant capture with stable retention. Herein, a layer cellulose-based sandwich (PCP) sponge with directionally aligned channels was fabricated through directional freezing and chemical cross-linking of cellulose fibers with chitosan and…
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Beyond total lead (Pb) content: speciation as a key control on plastic toxicity

Beyond total lead (Pb) content: speciation as a key control on plastic toxicity

Despite recent regulatory efforts, large amounts of legacy plastics containing lead (Pb) additives continue to degrade in the environment. As plastics degrade to micro- and nanoscales, Pb can either be released into the environment or subsequently adsorb onto micro- and nanoplastics. This variability in Pb speciation, with each form displaying distinct leaching behaviour, complicates environmental risk assessment. Here, we compile a dataset of plastic debris collected from beaches worldwide,…
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Mapping the biological effects of micro- and nanoplastics in mammalian intestinal models: a scoping review

Mapping the biological effects of micro- and nanoplastics in mammalian intestinal models: a scoping review

CONCLUSION: This scoping review demonstrates that intestinal MNPL research has expanded rapidly but remains methodologically concentrated in simplified in vitro systems and dominated by a limited range of polymer types and particle conditions. Although existing studies have generated important mechanistic insights, future progress will depend on the broader use of physiologically representative intestinal models, environmentally relevant polymers, and more standardized physicochemical…
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Domestic and wild animals as sentinels for environmental monitoring of emerging contaminants: a One Health framework for biomonitoring and human exposure assessment

Domestic and wild animals as sentinels for environmental monitoring of emerging contaminants: a One Health framework for biomonitoring and human exposure assessment

Emerging contaminants are increasingly detected across environmental, domestic, agricultural and food-chain matrices, where low-dose chronic exposure, mixtures, and delayed toxicological outcomes challenge conventional human-centred surveillance. This critical narrative review and monitoring-framework article uses structured keyword selection and literature mapping informed by SANRA quality criteria to integrate evidence on companion animals, livestock and wildlife as sentinels of per- and…
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Polymer-specific nanoplastic exposure, mitochondrial dysfunction, and depressed ejection fraction in humans

Polymer-specific nanoplastic exposure, mitochondrial dysfunction, and depressed ejection fraction in humans

CONCLUSIONS: Nanoplastic exposure is associated with left ventricular systolic function in humans and induces polymer-specific cardiomyocyte remodeling in vitro. PS is strongly linked to systolic impairment, consistent with a mitochondria-centered cardiotoxic phenotype. These findings identify nanoplastics as a previously unrecognized environmental determinant of myocardial vulnerability and support polymer-specific risk stratification.
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Natural Products as Protective Modulators of Environmental Pollutant Toxicity Through the Gut-X Axis

Natural Products as Protective Modulators of Environmental Pollutant Toxicity Through the Gut-X Axis

Environmental pollutants, including heavy metals, endocrine-disrupting chemicals, particulate matter, persistent organic pollutants, pesticides, and micro/nanoplastics, perturb the gut microbiome and intestinal barrier and propagate oxidative, inflammatory, metabolic, and epigenetic injury through interconnected gut-organ axes. This narrative review reframes the gut-X axis as a mechanistic platform for evaluating natural products as protective agents against pollutant toxicity. We summarize…
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Co-contamination of aquatic food animals by microplastics, heavy metals, and pesticides: bioaccumulation, human health risk, and role of artificial intelligence

Co-contamination of aquatic food animals by microplastics, heavy metals, and pesticides: bioaccumulation, human health risk, and role of artificial intelligence

Aquatic food animals provide essential proteins, omega-3 fatty acids, and micronutrients to billions of people worldwide, yet their safety is increasingly challenged by the co-occurrence of microplastics (MPs), heavy metals (HMs), and pesticides in aquatic ecosystems. Unlike previous reviews that examine these contaminant classes separately, this review presents an integrated framework linking contamination sources, bioaccumulation, trophic transfer, human health risks, food security, and…
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Dietary components regulate the gastrointestinal fate of polystyrene nanoplastics through differential aggregation, mucus transport and Caco-2 cell interactions

Dietary components regulate the gastrointestinal fate of polystyrene nanoplastics through differential aggregation, mucus transport and Caco-2 cell interactions

Micro(nano)plastics (MNPs) behaviour in the gastrointestinal (GI) tract is modulated by co-ingested food components, yet these effects remain poorly quantified. This study aimed to investigate how ghee, casein, and cellulose influence the transformation and cellular interactions of 200 nm polystyrene (PS) under simulated GI digestion. Changes in PS aggregation were evaluated in stomach and small intestinal digesta by the flow cytometer. The potential mucus penetration capacity of digested PS…
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Prepregnancy Exposure to High Doses of Nanoplastics Triggers Persistent Vaginal Microbiome Dysbiosis to Induce Adverse Pregnant Outcomes

Prepregnancy Exposure to High Doses of Nanoplastics Triggers Persistent Vaginal Microbiome Dysbiosis to Induce Adverse Pregnant Outcomes

The global accumulation of nanoplastics poses wide concerns for human health. Although their toxicity in various organs is being uncovered, their impact on vaginal microbiomes that are essential for healthy reproduction remains largely unknown. Here, we discover a previously unrecognized long-term nanoplastic reproductive toxicity that prepregnant exposure to high doses of aged polystyrene nanoparticles (aPS-NPs) induces mouse miscarriage and restricts embryo development by persistently causing…
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Emerging Contaminants and Male Reproductive Health: Mechanistic Insights, Clinical Evidence, and Research Priorities

Emerging Contaminants and Male Reproductive Health: Mechanistic Insights, Clinical Evidence, and Research Priorities

Male infertility contributes to around 40-50% of the infertility cases worldwide. Emerging environmental pollutants (microplastics, engineered nanoparticles, radiofrequency electromagnetic radiation (RF-EMR), pharmaceuticals and personal care products (PPCPs)) have received significant attention because of their environmental persistence and potential adverse effects on male reproductive health. This review critically synthesizes evidences from experimental, epidemiological and systematic…
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