CONCLUSIONS: Patients with HFexp have a slightly higher risk of cancer overall, but this may vary according to cancer type. Patients with both cancer and HFexp have a poor prognosis with a similar proportion of deaths attributed to cancer and cardiovascular disease.

Life’s Essential 8 (LE8) provides a multidimensional framework to assess cardiovascular health (CVH) in aging populations. The objective of this study was to describe LE8 component scores and their variation by age, sex, and psychosocial factors in middle-aged and older adults from Cádiz, Spain. Cross-sectional data were analyzed from 495 adults aged 50-79 years (59.4% women; 34.7% ≥ 65 years). LE8 scores were calculated following American Heart Association guidelines. Group comparisons used…

BACKGROUND: People living with HIV have an increased risk of cardiovascular disease, but data on the development and consequences of hypertension remain limited. Using data from REPRIEVE, a global randomised trial of pitavastatin for primary cardiovascular prevention among people with HIV, we evaluated whether pitavastatin reduces the incidence of hypertension among participants without hypertension at baseline and whether incident hypertension is associated with subsequent major adverse…

The common ACTN3 R577X polymorphism leads to α-actinin-3 deficiency in ~20% of the human population and may be detrimental to their muscle power. However, the impact of ACTN3R577X on metabolic health and exercise capacity in the general population remains unclear. The objective of the current study was to compare metabolic health markers, musculoskeletal traits, and cardiorespiratory capacity between untrained overweight α-actinin-3-deficient (XX; 20 men and 19 women) and α-actinin-3 expressing…

BackgroundInterstitial lung disease (ILD) patients often have comorbid chronic ischemic heart disease (CIHD), which may worsen prognosis. Large-scale studies on long-term CIHD mortality trends in ILD patients are lacking. This study analyzes CIHD-related mortality trends in US adults with ILD from 1999 to 2023.MethodsCIHD-related mortality data were extracted from the CDC WONDER database for ILD patients aged ≥25 years. International Classification of Diseases, 10th Revision (ICD-10) codes…

Background: COVID-19 has been associated with persistent impairments in autonomic modulation of heart rate variability (HRV). However, whether disease severity during the acute phase influences the magnitude of these impairments remains insufficiently explored. In turn, aerobic physical training (APT) has been proposed as a countermeasure to autonomic dysfunction of HRV in different conditions, although its effects in individuals with COVID-19 are not yet well established. To address these gaps,…

Cardiovascular disease (CVD) is a leading cause of mortality in men with prostate cancer (PC), with non-Hispanic Black (NHB) men experiencing disproportionately higher CVD-related mortality compared to non-Hispanic White (NHW) men. Vascular endothelial dysfunction precedes overt CVD; however, the mechanisms underlying racial disparities in CVD among men with PC remain unclear. This study tested the hypothesis that NHB men with PC would exhibit impaired vascular health compared to NHW men….

BackgroundDiabetes is a recognized risk factor for dementia, but its impact on dementia burden across sociodemographic groups in Australia is not well characterized.ObjectiveTo compare prevalence of dementia among Australians with and without diabetes and examine variation across key sociodemographic factors.MethodsWe conducted a cross-sectional analysis of the 2021 Australian national census among respondents aged 60-99 years. Prevalence was stratified by education, income, socioeconomic…

CONCLUSIONS: In long-term follow-up of individuals with mild initial COVID-19 and no prior structural heart disease, aerobic capacity relative to predicted values was reduced in 48% of participants, particularly in men, and was independently associated with higher myocardial native T1. Native T1 and resting lactate, but not conventional structural measures or peak exercise.