Category Archives: Men’s Health

Cardiovascular disease remains the leading cause of death in the United States, with heart failure (HF) and hyperlipidemia substantially contributing to mortality. This study aimed to examine national trends in HF-related mortality with coexisting hyperlipidemia from 1999 to 2024 and project future mortality patterns through 2035. Mortality data were obtained from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database. Deaths were…

CONCLUSIONS: Racial differences in LHC’s and LCD associated with ORM persist and the scale varies by subpopulation. Future interventions designed to prevent/manage ORM are crucial to prioritize populations burdening with high LHC’s and health disparities.

Cardiovascular-kidney-metabolic (CKM) syndrome was formalized by the American Heart Association in 2023 to capture the biological and clinical continuum linking excess adiposity, metabolic dysfunction, chronic kidney disease (CKD), and cardiovascular disease (CVD). Population-based studies indicate that CKM stage ≥1 affects approximately three-quarters to nine-tenths of adults in contemporary cohorts, with stage 2 consistently representing the largest population reservoir. Importantly, CKM…

CONCLUSIONS: In patients with CHF, a higher NLR was associated with greater congestion and poorer prognosis. The efficacy of empagliflozin was consistent, regardless of baseline NLR.

CONCLUSION: These findings suggest a potential role for IL-6 signaling in the autocrine regulation of IL-6 release from the contracting leg during exercise. Furthermore, exercise increases leg-derived sIL-6R, thereby contributing to increased circulating sIL-6R concentrations, while receptor-mediated splanchnic clearance appears to be a major determinant of systemic IL-6 availability during exercise in humans.

Pain modulation arising from the cardiovascular system has repeatedly been described. It is mediated by the baroreceptor system, where the activity of baroreceptor afferents inhibits nociception. Body posture changes cause blood volume redistribution that might modulate baroreceptor activity and antinociceptive effects. This study investigated posture-related differences in pain perception and their causation by cardiovascular factors. Pressure pain threshold and tolerance and pain intensity…

CONCLUSION: Higher adiposity is causally associated with a higher risk of infection-related mortality in Mexican adults. Strategies to reduce the population levels of adiposity in Mexico could contribute to lowering mortality from infection.

CONCLUSIONS: Applying a high income country derived CVD risk prediction equation to a population from a non-high income country with diabetes may introduce systematic errors, primarily driven by differences in the effect of age. Moving beyond simple recalibration to updating key predictor coefficients, particularly age, should be considered for more accurate risk stratification. This study highlights potential limitations of high income country equation updating practices and proposes a feasible…

CONCLUSIONS: Elevated cTnI levels with macrotroponin remained elevated for several years in asymptomatic individuals in this community-based cohort. While interpreting elevated cTnI levels in the clinical context, recording macrotroponin as a diagnosis could alert clinicians to possible artefactual elevation of cTnI levels during subsequent clinical presentation and avoid inappropriate investigation and management.

CONCLUSIONS: Gender identity is associated with differences in HF incidence and trajectory among veterans. HF epidemiology may be incompletely characterized without inclusion of TGD populations.