Sex and Age Differences in Outcomes After Endovascular Thrombectomy of Patients With Acute Ischemic Stroke and Atrial Fibrillation: A Danish Nationwide Study

Sex and Age Differences in Outcomes After Endovascular Thrombectomy of Patients With Acute Ischemic Stroke and Atrial Fibrillation: A Danish Nationwide Study

CONCLUSIONS: Among patients undergoing EVT for large vessel occlusion stroke in Denmark, women with AF had higher odds of good functional outcome and men with AF showed higher successful reperfusion rates with advancing age. Safety and mortality outcomes were similar across groups with AF. These findings suggest age-and sex-specific influences on EVT outcomes associated with AF.
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Indian Delphi consensus on cardiovascular risk mitigation in prostate cancer management

Indian Delphi consensus on cardiovascular risk mitigation in prostate cancer management

CONCLUSION: With increasing use of ADT and ARPIs and the high burden of cardiovascular comorbidities in Indian men with PCa, proactive cardiovascular risk assessment, individualized treatment selection, and coordinated multidisciplinary management are essential. This expert consensus provides actionable, India-specific guidance to balance oncologic efficacy with cardiovascular safety and improve long-term outcomes and quality of life for patients.
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Health Consequences of Spousal Health Shocks: Evidence from a Matched Event Study in the United States

Health Consequences of Spousal Health Shocks: Evidence from a Matched Event Study in the United States

Major disease diagnoses can create shocks that ripple through households. Population-level evidence in the U.S. on how spouses and partners fare after a partner’s major diagnosis remains sparse and is often limited to caregivers or employment-related outcomes. Using the U.S. Health and Retirement Study (1992-2020), we evaluated population-level health spillovers to spouses after a partner’s first diagnosis of cancer, stroke, or heart disease, using a stacked event-study design with matching (n =…
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Mortality in Castration Resistant Prostate Cancer Patients With and Without Pre-Existing Cardiovascular Disease Receiving Oral Androgen Receptor Pathway Inhibitors

Mortality in Castration Resistant Prostate Cancer Patients With and Without Pre-Existing Cardiovascular Disease Receiving Oral Androgen Receptor Pathway Inhibitors

CONCLUSION: In this population-based cohort of older men with castration-resistant prostate cancer, treatment with oral androgen receptor pathway inhibitors was associated with lower estimated risks of all-cause and prostate cancer-specific mortality compared with chemotherapy in patients with and without pre-existing CVD. These findings add real-world comparative effectiveness evidence for patient populations not well represented in randomized clinical trials; however, given the observational…
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Associations of testosterone, sex hormone-binding globulin, and related hormones with risks of cancer death, incident cancer, and incident prostate cancer in men: individual participant data meta-analyses

Associations of testosterone, sex hormone-binding globulin, and related hormones with risks of cancer death, incident cancer, and incident prostate cancer in men: individual participant data meta-analyses

BACKGROUND: Whether differences in sex hormones influence cancer risk in men remains uncertain. We aimed to clarify the association of circulating testosterone, sex hormone-binding globulin (SHBG), and related hormones with risks of cancer death, incident cancer, and incident prostate cancer by means of individual participant data (IPD) meta-analyses.
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Visual Impairment and Cardiovascular Risk Factors in Hispanic and Latino Adults

Visual Impairment and Cardiovascular Risk Factors in Hispanic and Latino Adults

CONCLUSIONS AND RELEVANCE: In this cross-sectional study of US Hispanic/Latino adults, VI and CVD risk factor prevalence varied by ethnic background, and diabetes and cumulative CVD risk factors were associated with VI. The findings provide updated prevalence estimates and support the need for longitudinal studies of causal relationships between VI and CVD risk factors.
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Global trends in the prevalence of type 2 diabetes mellitus: understanding trajectories through conceptual frameworks

Global trends in the prevalence of type 2 diabetes mellitus: understanding trajectories through conceptual frameworks

CONCLUSIONS: Global T2DM prevalence reflects the interaction of biological, social, and health system processes rather than incidence alone. Prevalence trajectories must be interpreted in light of surveillance limitations, diagnostic context, and within-disease heterogeneity. Addressing future burden requires combining improved detection and chronic-care capacity with upstream, life-course-oriented prevention strategies.
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