Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation
Nanoplastics are ubiquitous by-products of global plastic production and have emerged as a potentially consequential yet insufficiently defined threat to health. Recent studies have revealed that these synthetic particulates can cross the blood-brain barrier, accelerate amyloid aggregation, impair microglial clearance, hijack the gut-liver-brain axis, and drive neuroinflammation-mechanisms central to neurodegeneration in Alzheimer’s and Parkinson’s disease. In addition, anionic nanoplastics can…