Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation

Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation

Nanoplastics are ubiquitous by-products of global plastic production and have emerged as a potentially consequential yet insufficiently defined threat to health. Recent studies have revealed that these synthetic particulates can cross the blood-brain barrier, accelerate amyloid aggregation, impair microglial clearance, hijack the gut-liver-brain axis, and drive neuroinflammation-mechanisms central to neurodegeneration in Alzheimer’s and Parkinson’s disease. In addition, anionic nanoplastics can…
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Toxicological effects of polypropylene nanoparticles similar in size to nanoplastics in plastic-bottled injections on mice and zebrafish

Toxicological effects of polypropylene nanoparticles similar in size to nanoplastics in plastic-bottled injections on mice and zebrafish

Nanoplastics may threaten human health, most current toxicological studies focus on polystyrene, but no study on polypropylene (PP) in plastic bottled injections for medical care. Based on the amount of nanoplastic from PP-bottled injections introduced by intravenous infusion average daily in infants (31.5 ng) and adolescents (157.5 ng), we explored the toxicological effects of PP-NPs on the organ development of zebrafish. We also investigated the toxicological effects in mice of PP-NPs at doses…
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