Category Archives: Microplastics & Environmental Health

Widespread environmental contamination with nanoplastics (NPs) poses a significant risk to human health, particularly their accumulation in the central nervous system (CNS). This review examines how NPs can breach biological barriers, including the blood-brain barrier (BBB), olfactory system, and gut-brain axis, to access the brain. After their uptake by neurons through endocytosis, NPs primarily accumulate in the mitochondria, triggering cascades of neurotoxic changes in the brain. Existing…

CONCLUSIONS: Our findings demonstrated that PS-NPs exposure aggravated retinal inflammation and photoreceptor degeneration by microglial SPP1 signaling activation and NETs formation, underscoring new insights into the effects and potential targets of MNPs exposure on retinal disorders.

Micro- and nanoplastics (MNPs) are widespread environmental pollutants, with increasing evidence of human exposure through multiple routes. Their detection in human tissues, including the lungs, raises concerns about their potential impact on respiratory health, including lung cancer (LC). This review synthesizes current evidence on the biological effects of MNP exposure, with a focus on mechanisms potentially relevant to LC. In particular, extracellular vesicles (EVs) are discussed as mediators…

Chronic inhalation exposure to nanoplastics, specifically polyethylene terephthalate (PET) nanoplastics (PET-NPLs) is an emerging health concern, yet the long-term consequences for genomic stability and DNA damage response (DDR) capacity in bronchial epithelial cells remain poorly characterized. For this study, human bronchial epithelial BEAS-2B cells were continuously exposed to PET-NPLs for over 20 weeks, after which elevated basal DNA genotoxic damage was observed, as assessed by the alkaline…

Concerns about human exposure to micro- and nanoplastics (MNPLs), particularly nanoplastics (NPLs), have intensified in recent years. Consequently, there is a growing need for validated quantitative analytical methods capable of assessing NPLs in complex human biological matrices. Current approaches for NPL analysis are still limited by the absence of standardised protocols, difficulties in avoiding background contamination, and challenges associated with the selective identification and…

The pervasive environmental presence of micro- and nanoplastics (MNPs), combined with their ability to cross biological barriers and accumulate in the brain, has raised significant concerns regarding their neurotoxic potential. While neuroinflammatory and neurodegenerative effects are increasingly documented, a focused synthesis of their impact on depression-relevant behaviors is lacking. This systematic review evaluates the evidence linking MNPs exposure to depressive-like phenotypes across…

The impact of plastic particles on living organisms must be studied to develop monitoring and other environmental protection activities. Baikal endemic gastropods, Benedictia baicalensis, were cultivated for nine months in the presence of fluorescently labeled polystyrene (PS) and polyvinyl chloride (PVC) nanoparticles with a diameter of 80-150 nm at concentrations of 0.01, 0.1 and 1 mg/L. Light, laser confocal microscopy, and scanning electron microscopy methods were used to characterize the…

PURPOSE OF REVIEW: This review examines micro- and nanoplastic (MNP) exposure as an emerging risk factor for atherosclerotic cardiovascular disease, focusing on how individual-level exposures shaped by behaviours, micro-environments, and lifestyle factors contribute to cumulative internal dose and cardiovascular risk.

The widespread occurrence of microplastics (MPs) and nanoplastics (NPs) in natural environments, along with their associated potential health risks, has garnered significant scientific interest. Compared to MPs, NPs have a smaller particle diameter and a substantially larger surface-to-volume ratio. Therefore, NPs are hypothesized to pose a greater risk than MPs. In this study, we employed a multimodality approach combining pre-processing, transmission electron microscopy, and energy-dispersive…

Microplastic pollution is a major environmental problem affecting ecosystems, wildlife and people worldwide. Microplastics are solid synthetic polymer particles > 5 mm, insoluble in water and potentially containing functional additives and adsorbed chemical contaminants. They originate from bulk industrial products and from the degradation of large plastic debris (EFSA CONTAM Panel, in EFSA Journal 14, 2016). The extent of the contamination is critical, with global plastic production projected…