Tag Archives: MicroPlastics

Micro- and nano-plastics (MNPs) are widely distributed across global ecosystems and have been extensively detected in human tissues, including the brain. The levels of MNPs are highly correlated with the occurrence of various brain disorders, suggesting the potential central nervous system (CNS) toxicity of MNPs. In this review, we summarize the major circuits by which MNPs may transport into and out of the CNS, including blood-brain barrier crossing, nasal-to-brain routes, and glymphatic system…

Resulting from the widespread global adoption of plastic products, the ubiquitous contamination by micro- and nanoplastics (MNPs) now affects nearly every ecosystem, with aquatic environments serving as a primary sink for a vast portion of this pollution. These particles enter the food web, leading to bioaccumulation and posing a potential threat to ecosystems and human health. Conventional filtration systems exhibit limited efficiency to mitigate the growing threat of small MNPs: paradoxically,…

Accurately quantifying and characterizing human internal exposure to micro- and nanoplastics are critical for assessing potential health risks. However, the detection of these particles in human tissues, fluids, cell systems, and relevant models remains a major analytical challenge. There is an urgent need for robust, selective, sensitive, and high-throughput methods capable of generating reliable quantitative data. Equally essential is the transparent reporting of methodological limitations and…

Micro-(nano)-plastics (MNPs; <5 mm plastic particles including nanoscale fractions) are increasingly recognized as pervasive environmental pollutants, with risks arising not only from their original emission sources but also from ongoing transformations. This review systematically integrates current evidence on the formation and transformation of MNPs under mechanical, photochemical, thermal, oxidative, and biological processes, highlighting that environmental MNPs are predominantly aged rather…

Nanoplastics (NPs) pose a significant threat to ecosystems and human health due to their diminutive size and high potential for bioaccumulation. Most existing membranes for NPs separation, however, are composed of non-biodegradable, petroleum-based polymers that are difficult to recycle. This study introduces the development of an eco-friendly collagen fibrous membrane (CFM) with a hierarchical structure designed for NPs capture, achieved through crosslinking CFM with a polyphenol-Al^(3 +)…

Mechanical recycling and other processes involved in the end-of-life treatment of 3D-printed plastic polymers can lead to the generation of micro- and nanoplastics (MNPs). As the use of these materials continues to grow, the mechanical degradation of plastics from 3D printing may increase human exposure to MNPs, raising concerns about potential health risks for users and environmental impacts. One of the main routes of exposure to MNPs is via inhalation. For regulatory purposes, most of…

Micro/nanoplastics (MNPs), ranging from 25 nm to 10 μm, have emerged as ubiquitous environmental pollutants, with an increasing body of research exploring their potential risks to male reproductive health. This review provides a synthesis of the observed impacts of MNPs on spermatogenesis, focusing on cellular fate, homeostatic disruption, and potential intergenerational consequences. Evidence from experimental models, utilizing dosages from 50 μg/kg/day to 75 mg/kg/day, suggests that MNPs may…

In response to the plastic pollution crisis, bioplastics emerged as a sustainable alternative. However, low degradation rate and abiotic decomposition generate micro- and nanoplastics. These particles enter the food chain, establishing oral intake as a key route of human exposure. This review gathered studies on the biotransformation of bioplastics in the gastrointestinal tract and on their toxicity in human cells and murine models. Most studies focused on polylactic acid particles due to…

Human exposure to micro- and nanoplastics is increasingly recognized as a global concern, yet their long-term effects on human health remain poorly understood. Defining the cellular consequences of chronic exposure is essential for reliable risk assessment and informed environmental and public health strategies. Here, we investigated the impact of prolonged culture in presence of nanoplastics, using an in vitro hepatocyte model (HepG2) exposed to environmentally relevant concentrations (10⁴ and…

Micro/nanoplastics (M/NPs) are ubiquitous emerging contaminants that have permeated all trophic levels of global ecosystems. The gut microbiota, which serves as the central hub for host metabolic homeostasis, immune defense, and neuromodulation, is a confirmed critical amplifier of M/NP-induced toxic effects. This review describes the links between M/NP exposure, gut dysbiosis, intestinal barrier impairment, and systemic multiorgan injury. We compared microbial changes across diverse aquatic and…