Human Exposure to Micro- and Nanoplastics and Their Potential Neurological Implications: A Systematic Review of Emerging Evidence

The growing prevalence of micro- and nanoplastics (MNPs) in the environment elicits concerns about their possible impact on human neurological health. Although studies on animals have suggested neurotoxic effects, evidence from humans is still scarce. This systematic review gathers existing human data to assess the presence, types, detection techniques, and neurological consequences of MNPs in different biological matrices. A comprehensive review was performed on peer-reviewed research…

Network toxicology deciphers micro- and nanoplastics-mediated mixture hazard, predictive risk assessment, and regulatory translation

Micro- and nanoplastics (MNPs) are pervasive environmental contaminants and efficient carriers of coexisting pollutants, including heavy metals, organic chemicals, and antibiotics. Their capacity to adsorb, transport, and release contaminants has raised growing concern over mixture toxicity under realistic exposure scenarios. This review systematically examines the mechanistic basis of MNPs-mediated combined toxicity and evaluates the emerging role of network toxicology as a systems-based tool…

First study on the toxicokinetic approach of MNPs in an environmentally exposed human population, through their evaluation in blood and urine samples by Pyr-GC-MS and multivariate analysis

Exposure to MNPs represents an emerging risk for human health. This study provides a comprehensive profile of ten polymers in blood and urine from 98 volunteers in an environmentally exposed population. MNPs were morphometrically characterized prior to quantification by Pyr-GC-Orbitrap-MS. Data were processed through independent bivariate and multivariate analyses to determine polymer compartmental partitioning in both matrices. All participants tested positive for at least one polymer with a…

Emerging role of microplastics and nanoplastics in children’s health

Plastics are a growing environmental and health threat. Microplastics (MPs, <5 mm) and nanoplastics (NPs, <1 μm) are pervasive environmental contaminants increasingly detected within human tissues, including placenta, cord blood, breast milk, and infant stool, highlighting chronic early-life exposure. Children represent a uniquely vulnerable population due to higher intake relative to body mass, immature detoxification and immune systems, and rapid organogenesis. MPs and NPs (MNPs) can traverse…

Micro- and Nanoplastics as Emerging Drivers of Liver Injury: Exposure, Evidence, and Mechanisms

Micro- and nanoplastics (MNPs) are emerging environmental contaminants of increasing relevance to human health. Growing evidence suggests that, following ingestion, inhalation, or, less convincingly, dermal exposure, MNPs may cross biological barriers, enter lymphatic and vascular compartments, and reach the liver. Owing to portal blood flow, sinusoidal architecture and Kupffer cell activity, the liver appears to be one of the principal sites of early particle sequestration. Human biomonitoring,…

Dietary Intake of Micro- and Nanoplastics: Potential Adverse GI Effects on Microbiome, Inflammation, and Neoplasia

Micro- and nanoplastics (MNPs) are pervasive in food-contact environments and the human diet, positioning the gastrointestinal (GI) tract as the primary portal of entry and a plausible site of early biological effects. Human exposure is supported by detection of microplastics in stool and colon tissue, and emerging clinical studies report associations between fecal microplastic burden and GI disease states, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). Preclinical…

Micro- and Nanoplastics as Potential Drivers of Dilated Cardiomyopathy

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, but up to 50% of cases have no definitive etiology. Genetic susceptibility alone does not account for phenotypic inconsistency, so a ‘two-hit’ model has been proposed to explore the spectrum of gene-environment interactions. Certain triggers, such as alcohol, chemotherapy agents, and viral myocarditis, are well-established second hits in the pathogenesis of DCM. The exposome, which encompasses environmental and social exposures…

Detection and release characterization of micro-nanoplastics from kitchen plastic products: A review

Kitchen-derived micro-nanoplastics (M/NPs) have emerged as a potential source of human dietary M/NP exposure, yet their release mechanisms, particle characterization, and associated health risks remain poorly understood. This review systematically summarizes the current research on household kitchen plastic products, categorizing them into cooking auxiliaries, cleaning products, food containers, and others. Among them, plastic food containers are the primary contributors to kitchen-derived M/NP…

Transcriptomic responses to repeated exposure of human C3A liver spheroids to polystyrene nanoplastics

Increasing evidence of nanoplastics (NPs) accumulation in the human liver has raised concerns regarding their potential hepatotoxicity. However, current knowledge is largely derived from animal studies or simplistic in vitro models, often with unrealistic exposure scenarios, thereby constraining their relevance to human health. Human liver spheroids have emerged as relevant tools for long-term mechanistic toxicological studies, yet their application to the hepatotoxicity assessment of NPs…

Nano-plastic contamination in soil: impacts on rhizosphere volatile organic compound (VOC) signaling and rice disease susceptibility-a comprehensive review

Polyvinyl chloride nanoplastics (PVC-NPs) are emerging pollutants that pose a significant threat to agricultural soils, where they may disrupt rhizosphere volatile organic compound (VOC) signaling and intensify rice blast disease caused by Magnaporthe oryzae. The widespread use of PVC-NPs may result in their accumulation in rice-cultivated soils, where their physicochemical properties interfere with and adversely affect the soil microbial communities and root physiology. Evidence from recent…