Curcumin attenuates nanoparticle-induced renal injury <em>via</em> the PI3K/AKT signaling pathway

Curcumin attenuates nanoparticle-induced renal injury via the PI3K/AKT signaling pathway

Polystyrene nanoplastics (PS-NPs) primarily originate from nanoscale fragments formed through weathering, mechanical abrasion, and biodegradation of polystyrene plastics under natural conditions. Exposure to PS-NPs endangers human health, so exploring curcumin’s (Cur) nephroprotective effects against PS-NPs-induced injury is crucial. This research integrated network pharmacology with in vitro and in vivo assays and conducted validation using the PI3K inhibitor LY294002. Experimental results…

Spectroscopic studies on polystyrene nanoparticle-induced changes in the structure and properties of human serum albumin

Nanoplastics are considered a potential threat to human health and the environment due to their persistence and ubiquity. Upon entrance into the biological systems, nanoplastics can interact with proteins, forming “protein corona”. In this study, the interactions of polystyrene nanoparticles (PSNPs) with human serum albumin (HSA) were investigated by multiple spectroscopic techniques. UV-Vis spectroscopic and spectrofluorimetric studies demonstrated that PSNPs formed a spontaneous ground-state…

Warning: Microplastics Are No Longer Just an Environmental Issue

The Growing Concern About Plastic Exposure Inside the Human Body

For years, plastic pollution was treated mostly as an environmental problem—something floating in oceans, washing onto beaches, or collecting in landfills.

That understanding has changed dramatically.

Researchers are now finding microscopic plastic particles not only in the environment, but inside the human body itself.

Microplastics and nanoplastics have been detected in drinking water, food, household dust, blood, lungs, reproductive tissues, and even human organs. While scientists are still studying the full long-term impact of this exposure, one thing is becoming increasingly clear:

Modern life has created constant contact with plastic particles that most people never see and rarely think about.

Metal-phenolic network-assisted electrochemical selective tracking of polystyrene nanoplastic particles in drinking water

Nanoplastics (NPLs) are emerging contaminants of growing concern due to their persistence, bioavailability, and potential risks to aquatic ecosystems and human health. Yet, their detection remains challenging even in bottled drinking water due to low cost, selectivity, and sensitivity. Herein, we report a mechanism-driven electrochemical sensing strategy for polystyrene nanoplastics (PS NPLs) based on the formation of a metal-phenolic network (MPN). Tannic acid (TA) exhibits strong and selective…

Micro- and Nanoplastics in the Human Brain: Mechanistic Plausibility, Translational Challenges, and Links to Neurological Disease Trends

The exponential growth in plastic production since the mid-twentieth century has led to the pervasive presence of micro- and nanoplastics (MNPs) across ecosystems and human exposure pathways, coinciding with a rising global burden of neurological disorders. Increasing evidence demonstrates that MNPs are not confined to peripheral tissues but can accumulate even in the human brain, raising concerns about their potential contribution to neurological disease. This structured review synthesizes…

The bioaccumulation and carcinogenic potential of micro- and nanoplastics in humans

The rising concentrations of anthropogenic microplastics (MPs; 1 µm to 5 mm) and nanoplastics (NPs; < 1 µm) pollution pose a global crisis, presenting a grave threat to the ecosystem and the health of living creatures within. Studies between 2024 and 2025 reported the bioaccumulation of MPs and NPs (MNPs) in several human organs. However, unlike animal and cell line studies, the relationship between MNPs exposure and carcinogenesis in humans remains unclear. To our knowledge, this is the first…

Health Risks of Prenatal and Early-Life Microplastics Exposure: A Comprehensive Review

Microplastics (MPs) and nanoplastics (NPs) are emerging environmental contaminants that have raised increasing concern regarding their potential health effects. During pregnancy and early life, developing organisms are particularly vulnerable due to immature biological barriers and the dynamic nature of organogenesis. This review summarizes current evidence on maternal and early life exposure routes to MPs and NPs, including oral ingestion, inhalation, dermal contact, and transplacental…

Reassessing Toxicity Claims of Micro- and Nanoplastics in Human Health Research

No abstract

Exploring the Relationship Between Microplastic Exposure and Bone Health

The ubiquity of microplastics and nanoplastics (or microplastic and nanoplastic particles, collectively MNPs) in the modern environment has led to detection of polymer particles and polymer-associated chemicals repeatedly within human tissues and fluids, inevitably raising concern for long-term effects on organ systems, including the skeleton. Accumulated evidence over the last decade implicates MNPs and plastic-associated endocrine disrupting chemicals (EDCs), such as phthalates and bisphenols,…

Methodology, characterization, and multiple-path particle dosimetry modeling of laboratory inhalation exposure for micro-nanoplastic particles in rodents

Plastics are ubiquitous in all trophic environments. Human exposures primarily occur via ingestion, inhalation, and/or injection routes. However, laboratory models of micro- and nanoplastic (MNP) particle exposures replicating the human condition remain inconsistent and uncharacterized, thus limiting study strength and compromising the reliability of results. The purpose of this study was to thoroughly optimize and characterize an established methodology for MNP rodent inhalation exposures, and…