Comparing four training modalities on body composition, cardiorespiratory fitness and cardiovascular responses in sedentary young men: a randomized trial

CONCLUSIONS: These preliminary findings suggest outcome-specific differences among the training protocols. HIIT improved VO2peak more than MIIT, while high-intensity protocols showed greater improvements in selected cardiovascular responses. No adjusted between-group differences were detected for Bruce test duration, and no differential effects were observed for body composition. Larger controlled trials are needed to confirm these findings.

Cardiovascular events with esaxerenone versus spironolactone in hypertension

Mineralocorticoid receptor antagonists (MRAs) exhibit distinct pharmacologic profiles, yet their differential clinical relevance remains underexplored. This study assessed cardiovascular prevention with nonsteroidal esaxerenone (ESAX) relative to steroidal spironolactone (SPL) in hypertensive populations. From a nationwide claims database, we identified individuals with hypertension who newly initiated ESAX or SPL. Cardiovascular disease (CVD) was defined as a composite outcome of heart failure,…

Inpatient Initiation of Target-Dose ACE Inhibitors and Lower Risk of Death or Kidney Failure in Veterans With HFrEF: Results From the National DCVA-HF Registry

CONCLUSION: The observed renal safety and lower mortality in patients with HFrEF newly initiated on ACEIs at higher target doses before discharge support the use of this inpatient strategy and suggest it may help mitigate the persistent outpatient inertia in the initiation and up‑titration of evidence‑based HF therapies.

Temporal Trends in Multimorbidity Patterns in Patients With Atrial Fibrillation-A Nationwide Cohort Study

CONCLUSIONS: Multimorbidity is highly prevalent and increasing among patients with AF, highlighting the importance of a holistic management approach.

Associations of loneliness, social isolation and healthy lifestyle with life expectancy free of major physical disease and mental disorder

Loneliness and social isolation are linked to higher risks of mortality and a range of adverse physical diseases and mental disorders, yet the extent to which they affect overall health and quality of life remains unclear. Here we show that loneliness and social isolation are more strongly associated with life expectancy free of mental disorder than with life expectancy free of physical disease. This study includes 277,489 adults from the UK Biobank who are initially free of seven major chronic…

The association between obesity indices and hypertension in adults with different glycemic status: A population-based cross-sectional study of the Bandare-Kong cohort

Obesity and hypertension (HTN) frequently coexist with dysglycemia, yet it remains unclear whether general (BMI) versus central (waist circumference, WC) obesity indices show differential associations with HTN across normoglycemic, prediabetic, and diabetic states. This population-based study aimed to assess this relationship among adults aged 35 to 70 from the Bandare-Kong cohort. HTN was determined based on systolic blood pressure ≥130 mm Hg, diastolic blood pressure ≥80 mm Hg, or…

Longitudinal associations between positive psychological factors and cardiovascular health

CONCLUSION: Positive affect and life-satisfaction may benefit cardiovascular health by favorably affecting coagulation and inflammation, with potential implications for CHD prevention and intervention strategies.

Health related quality of life and cardiac symptoms following admission for suspected MINOCA: A post-hoc analysis of the MINOCA-BAT randomized clinical trial

CONCLUSIONS: Patients with a working diagnosis of MINOCA and preserved LV-EF constitute a low-risk population and demonstrate a favorable prognosis with symptom resolution within one year. Their HRQoL appears broadly similar to that observed in the general population, with only modest differences between the sexes.

Temporal Trends in Mortality Due to Ischemic Heart Disease and Cardiac Arrhythmias in the United States From 1999 to 2023

CONCLUSIONS: Although IHD-arrhythmia mortality declined between 1999 and 2023, substantial disparities persisted across demographic and geographic subgroups, highlighting the need for targeted public health interventions.

Effect of Testosterone Treatment on Leucocyte Telomere Length in Men: Results From a Randomised Placebo-Controlled Trial

CONCLUSIONS: There was no effect of testosterone treatment on telomere length in this group of men. Larger studies with longer treatment durations are merited.