Category Archives: Men’s Health

National long-term trends and disparities in deaths in which both chronic obstructive pulmonary disease (COPD) and cardiac arrest are recorded on death certificates are not well characterized. We used CDC WONDER Multiple Cause of Death data (1999-2023) to identify US adults aged ≥ 65 years whose death certificates listed both COPD (ICD-10 J41-J44) and cardiac arrest (I46) as underlying or contributing causes. Age-adjusted mortality rates (AAMRs) were stratified by sex, race/ethnicity, region,…

CONCLUSION: Patients with AIS demonstrated distinct sex-associated clinical profiles according to CKD status. Although several associations were numerically stronger among patients with CKD, formal interaction testing did not establish statistically significant effect modification. These findings characterize clinical heterogeneity among men and women with established AIS and warrant further investigation to determine whether these profiles have implications for treatment or outcomes.

CONCLUSIONS: In asymptomatic, intermediate-risk individuals, statin treatment was associated with a shift toward higher density calcium within coronary plaques, most marked with effective lowering of LDL-C. (Coronary Artery Calcium Score: Use to Guide Management of Hereditary Coronary Artery Disease [CAUGHT-CAD]; ACTRN12614001294640).

CONCLUSION: Obese individuals, particularly White males with comorbidities, were more likely to experience cardiac arrest, with atrial fibrillation being a strong independent risk factor even after adjustment for heart failure. Disparities in healthcare access were evident, with individuals of higher socioeconomic status more likely to receive ICDs, while certain racial groups had worse outcomes.

CONCLUSIONS: A small dose of alcoholic beer reduced the exercise capacity of healthy individuals, likely due to an impairment in running economy.

CONCLUSIONS: Diabetes, but not prediabetes, was independently associated with rapid progression of coronary atherosclerosis. Furthermore, the higher incidence of RPP among participants who developed new-onset diabetes suggests that the development of diabetes may represent an important threshold for accelerated coronary plaque progression.

CONCLUSIONS: Among patients with newly diagnosed atrial fibrillation at high risk for ischemic stroke, OAC prescribing at diagnosis was suboptimal, and loss of documented OAC prescribing was common during the first year. Baseline OAC use was more strongly associated with bleeding risk, frailty, and comorbidity burden, and less consistently aligned with ischemic stroke risk.

The abundance of diverse naive CD8^(+) T cell clones is essential for broad protection against infection and cancer, but how sex and aging jointly shape this compartment remains poorly understood. Here, using mouse models with supporting human data, we uncover a sex-biased mechanism of immune aging in which early male-biased depletion of naive CD8^(+) T cells driven by accelerated, antigen-agnostic differentiation into virtual memory cells combines with thymic involution, limiting naive CD8^(+)…

Several recent works have focused on predicting risk for incident cardiovascular disease (CVD) from routine sleep studies using AI. These works aim to utilize the breadth of multimodal sleep study signal data to better identify and stratify people who are more at risk for disease and specific groups that would benefit from therapy. The predominant sleep study cohorts used for CVD risk predictive modeling are the Sleep Heart Health Study (SHHS), the Multi-Ethnic Study of Atherosclerosis (MESA),…

CONCLUSIONS: Pronounced sex disparities in IHD population-level case fatality persist across Eastern Europe. Lithuania and the Republic of Moldova showed the most consistent female disadvantage. Excess female population-level case fatality was most consistently associated with key modifiable risk factors.