Exploring Associations Between Frequency and Methods of Cannabis Use and Tooth Loss

CONCLUSION: Frequent and smoked cannabis use are associated with poorer oral health outcomes, particularly increased tooth loss.

Associations of Life’s Essential 10 with Mortality and Healthspan Free of Cardiovascular Disease and Cancer: Findings in Two Nationwide Cohorts

CONCLUSION: Higher LE10-based CVH levels were associated with lower all-cause mortality, reduced CVD and cancer mortality and incidence, and longer life expectancy free of CVD and cancer. LE10 may provide additional targets for CVH management.

Physical inactivity attributable burden of disease on morbidity and mortality across Swiss language regions: a population-based modelling study

CONCLUSION: Results of this analysis suggest that physical inactivity significantly contributes to YLD and YLL rates in Switzerland, with pronounced regional and sex-specific disparities. The higher burden of disease observed in the Italian- and French-speaking regions highlights the need for regionally tailored prevention strategies that address cultural and contextual differences.

Biological sex, socioeconomic position, and stress physiology among Native Americans: Findings from the Oklahoma Study of Native American Pain Risk III

Native Americans (NAs) experience disproportionate exposure to chronic sociocultural stressors that may shape physiological stress systems and contribute to health disparities. Yet, little research has examined acute stress reactivity, stress recovery, and their predictors in NAs. The present study investigated the independent and joint effects of sex and socioeconomic position (SEP) on sympathetic-adrenomedullary (SAM), hypothalamic-pituitary-adrenal (HPA), and negative affective responses to…

Contributions of diet and lifestyle to sex differences in ischaemic heart disease burden in Central Europe: an analysis of the Global Burden of Disease Study 2023

BACKGROUND: Central Europe carries a substantial global burden of ischaemic heart disease (IHD). We aimed to quantify sex-specific differences in IHD case-fatality across 13 Central European countries and to examine the contribution of metabolic, behavioural, and dietary risk factors to these disparities.

National trends in heart failure and hyperlipidemia related mortality in the United States, 1999-2024: Demographic and regional disparities with machine learning based forecasting to 2035

Cardiovascular disease remains the leading cause of death in the United States, with heart failure (HF) and hyperlipidemia substantially contributing to mortality. This study aimed to examine national trends in HF-related mortality with coexisting hyperlipidemia from 1999 to 2024 and project future mortality patterns through 2035. Mortality data were obtained from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database. Deaths were…

Racial differences in lifetime healthcare costs associated with obesity-related multimorbidity among the U.S. population aged 40 years or older

CONCLUSIONS: Racial differences in LHC’s and LCD associated with ORM persist and the scale varies by subpopulation. Future interventions designed to prevent/manage ORM are crucial to prioritize populations burdening with high LHC’s and health disparities.

Neutrophil-to-Lymphocyte Ratio in Patients With Heart Failure: Findings From The EMPEROR Program

CONCLUSIONS: In patients with CHF, a higher NLR was associated with greater congestion and poorer prognosis. The efficacy of empagliflozin was consistent, regardless of baseline NLR.

Autocrine Signaling may Regulate Exercise-Induced Interleukin-6 Release from Human Skeletal Muscle

CONCLUSION: These findings suggest a potential role for IL-6 signaling in the autocrine regulation of IL-6 release from the contracting leg during exercise. Furthermore, exercise increases leg-derived sIL-6R, thereby contributing to increased circulating sIL-6R concentrations, while receptor-mediated splanchnic clearance appears to be a major determinant of systemic IL-6 availability during exercise in humans.

CKM: Epidemiology, current clinical implications and future burden

Cardiovascular-kidney-metabolic (CKM) syndrome was formalized by the American Heart Association in 2023 to capture the biological and clinical continuum linking excess adiposity, metabolic dysfunction, chronic kidney disease (CKD), and cardiovascular disease (CVD). Population-based studies indicate that CKM stage ≥1 affects approximately three-quarters to nine-tenths of adults in contemporary cohorts, with stage 2 consistently representing the largest population reservoir. Importantly, CKM…